Drug Standards
Medchemexpress LLC Flavopiridol (Alvocidib) | 146426-40-6 | 99.4% | 401.84 | 100 MG
Flavopiridol (Alvocidib) is a broad-spectrum and competitive inhibitor of cyclin-dependent kinases (CDKs), effectively inhibiting CDK1, CDK2, and CDK4. It induces a distinct pattern of ER stress in CLL cells, contributing to cell death through IRE1-mediated activation of ASK1 and potentially downstream caspases. This compound also leads to potent upregulation of several primary response genes (PRGs) with both immediate and long-term effects on their expression. Furthermore, Flavopiridol inhibits cyclin E1 and induces apoptosis.
- Broad-spectrum and competitive inhibitor of CDKs
- Inhibits CDK1, CDK2, and CDK4
- Induces ER stress in CLL cells
- Contributes to cell death via IRE1-mediated activation of ASK1
- Upregulates primary response genes
- Inhibits cyclin E1
- Induces apoptosis
Selleck Chemical LLC Linsitinib (OSI-906) 10mM/1mL 867160-71-2
Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Tecoland Corp Fulvestrant | 129453-61-8 | MFCD00903953 | 1 g
Fulvestrant | Mol Wt: 606.77 | 129453-61-8 | MFCD00903953 | 1 g
Apexbio Technology LLC Fenoldopam 67227-56-9 10mg
Fenoldopam is a small-molecule partial agonist targeting dopamine D1-like receptors It is designed to selectively activate these receptors thereby mediating peripheral vasodilation and modulating vascular resistance Fenoldopam exerts its biological activity primarily through D1-like receptor activation In in vitro studies Fenoldopam demonstrates partial agonist activity with an EC50 value of approximately 57 nM Additionally it exhibits inhibitory activity against 2-adrenoceptors with a reported Ki of 15 25 nM Based on these pharmacological properties Fenoldopam holds research potential in studies of cardiovascular regulation receptor pharmacodynamics and selective receptor ligand profiling
Cayman Chemical ChlorambucIl-d8 1mg
An internal standard for the quantification of chlorambucil by GC- or LC-MS
Medchemexpress LLC Ticagrelor impurity 14 | 2408330-73-2 | C17H27ClN4O5S | 1 MG
Ticagrelor impurity 14 is an impurity of Ticagrelor (HY-10064).
- Recommended storage at -20°C.
- Keep sealed, away from moisture and light.
- In solvent, store at -80°C for 6 months or -20°C for 1 month.
Selleck Chemical LLC Verdinexor (KPT-335) 5mg 1392136-43-4 ATG-527
Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Doxylamine succinate | 562-10-7 | 99.8% | C21H28N2O5 | 1 G
Doxylamine succinate is a first-generation antihistamine, acting as a histamine (H1) receptor antagonist. It also functions as a local analgesic and an effective hypnotic agent.
- First-generation antihistamine
- Histamine (H1) receptor antagonist
- Local analgesic agent
- Effective hypnotic agent
Selleck Chemical LLC Methazolamide 50mg 554-57-4 CL 8490
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Benzylpenicillin potassium 113-98-4 250mg
Benzylpenicillin potassium (113-98-4) is a beta-lactam antibiotic targeting penicillin-binding proteins (PBPs) It is designed to inhibit bacterial cell wall biosynthesis by interfering with peptidoglycan cross-linking thereby reducing bacterial stability and inducing cell lysis Benzylpenicillin potassium exerts its biological activity primarily through inhibition of PBPs To date specific IC50 concentrations of Benzylpenicillin potassium vary according to bacterial strains experimental conditions and assay methodologies employed in antimicrobial susceptibility studies Based on these pharmacological properties Benzylpenicillin potassium holds research potential in investigating bacterial infections associated with blood cardiac tissue pulmonary structures joints and reproductive organs
Apexbio Technology LLC Econazole nitrate 24169-02-6 5g
Econazole nitrate (24169-02-6) is a small-molecule inhibitor targeting the enzyme 14 -demethylase It is designed to disrupt ergosterol synthesis in fungal membrane sterol biosynthesis thereby decreasing membrane integrity altering permeability and attenuating fungal cellular growth Econazole nitrate exerts its biological activity primarily through inhibition of 14 -demethylase In vitro studies demonstrate antifungal activity with reported IC50 values against various fungal isolates typically ranging from approximately 0 05 to 1 g/mL depending on experimental parameters and organism specificity Based on these pharmacological properties econazole nitrate holds research potential in antifungal susceptibility testing exploration of drug resistance mechanisms in fungal strains characterization of dermatopathogenic microorganisms and drug target identification studies